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^ 3.03.13.23.33.43.5
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^Spencer RC, Devilbiss DM, Berridge CW. The Cognition-Enhancing Effects of Psychostimulants Involve Direct Action in the Prefrontal Cortex. Biol. Psychiatry. June 2015, 77 (11): 940–950. PMID 25499957. doi:10.1016/j.biopsych.2014.09.013. The procognitive actions of psychostimulants are only associated with low doses. Surprisingly, despite nearly 80 years of clinical use, the neurobiology of the procognitive actions of psychostimulants has only recently been systematically investigated. Findings from this research unambiguously demonstrate that the cognition-enhancing effects of psychostimulants involve the preferential elevation of catecholamines in the PFC and the subsequent activation of norepinephrine α2 and dopamine D1 receptors. ... This differential modulation of PFC-dependent processes across dose appears to be associated with the differential involvement of noradrenergic α2 versus α1 receptors. Collectively, this evidence indicates that at low, clinically relevant doses, psychostimulants are devoid of the behavioral and neurochemical actions that define this class of drugs and instead act largely as cognitive enhancers (improving PFC-dependent function). This information has potentially important clinical implications as well as relevance for public health policy regarding the widespread clinical use of psychostimulants and for the development of novel pharmacologic treatments for attention-deficit/hyperactivity disorder and other conditions associated with PFC dysregulation. ... In particular, in both animals and humans, lower doses maximally improve performance in tests of working memory and response inhibition, whereas maximal suppression of overt behavior and facilitation of attentional processes occurs at higher doses.
^Ilieva IP, Hook CJ, Farah MJ. Prescription Stimulants' Effects on Healthy Inhibitory Control, Working Memory, and Episodic Memory: A Meta-analysis. J. Cogn. Neurosci. January 2015: 1–21. PMID 25591060. doi:10.1162/jocn_a_00776. Specifically, in a set of experiments limited to high-quality designs, we found significant enhancement of several cognitive abilities. ... The results of this meta-analysis ... do confirm the reality of cognitive enhancing effects for normal healthy adults in general, while also indicating that these effects are modest in size.
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Place in Moyen-Ogooué, Gabon Lambaréné Street in Lambaréné Lambaréné Location in Gabon Coordinates: 0°41′18″S 10°13′55″E / 0.68833°S 10.23194°E / -0.68833; 10.23194 Coordinates: 0°41′18″S 10°13′55″E / 0.68833°S 10.23194°E / -0.68833; 10.23194 Country Gabon Province Moyen-Ogooué Population (2013 census) • Total 38,775 Lambaréné is a town and the capital of Moyen-Ogooué in Gabon. With a population of 38,775 as of 2013, it is located 75 kilometres south of the equator. Lambaréné is based in the Central African Rainforest at the river Ogooué. This river divides the city into 3 districts: Rive Gauche, Ile Lambaréné and Rive Droite. The Albert Schweitzer Hospital and the districts Adouma and Abongo are located on Rive Droite. The districts Atongowanga, Sahoty, Dakar, Grand Village, Château, Lalala and Bordamur build the Ile Lambaréné. The majority of the people in Lambaréné live in the district Isaac located on Rive Gauche. This distr...
This article is about the number. For the year, see 800. For other uses, see 800 (disambiguation). Natural number ← 799 800 801 → List of numbers — Integers ← 0 100 200 300 400 500 600 700 800 900 → Cardinal eight hundred Ordinal 800th (eight hundredth) Factorization 2 5 × 5 2 Greek numeral Ω´ Roman numeral DCCC Binary 1100100000 2 Ternary 1002122 3 Quaternary 30200 4 Quinary 11200 5 Senary 3412 6 Octal 1440 8 Duodecimal 568 12 Hexadecimal 320 16 Vigesimal 200 20 Base 36 M8 36 800 ( eight hundred ) is the natural number following 799 and preceding 801. It is the sum of four consecutive primes (193 + 197 + 199 + 211). It is a Harshad number. Contents 1 Integers from 801 to 899 1.1 800s 1.2 810s 1.3 820s 1.4 830s 1.5 840s 1.6 850s 1.7 860s 1.8 870s 1.9 880s 1.10 890s 2 References Integers from 801 to 899 800s Main article: 801...
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