Hepatosplenomegaly
















Hepatosplenomegaly
Specialty
Gastroenterology Edit this on Wikidata

Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly). Hepatosplenomegaly can occur as the result of acute viral hepatitis, infectious mononucleosis, and histoplasmosis or it can be the sign of a serious and life-threatening lysosomal storage disease. Systemic venous hypertension can also increase the risk for developing hepatosplenomegaly, which may be seen in those patients with right-sided heart failure.




Contents






  • 1 Common causes


  • 2 Rare disorders


  • 3 References


  • 4 External links





Common causes





  • Infection:

    • Acute viral hepatitis[1][2]


    • Infectious mononucleosis[1][2]


    • Cytomegalovirus[1][2]


    • Rubella[1]


    • Brucella infection[3]


    • Hyper active malaria syndrome[1]


    • Leishmaniasis[1]

    • Fasciolosis


    • Typhoid fever[4]


    • Schistosomiasis or filariasis importants

    • Septicemic plague

    • Histoplasmosis




  • Hematologic diseases:


    • Myeloproliferative disease[1][2]


    • Leukaemia[1][2]


    • Lymphoma[1][2]


    • Pernicious anaemia[2]


    • Sickle cell anaemia[2]


    • Thalassaemia[2]


    • Myelofibrosis[1]




  • Metabolic disease:


    • Niemann-Pick disease[citation needed]


    • Gaucher's disease[citation needed]


    • Hurler's syndrome[citation needed]




  • Chronic liver disease and portal hypertension:

    • Chronic active hepatitis[2]



  • Amyloidosis[2]


  • Acromegaly[2]


  • Systemic lupus erythematosus[2]

  • Sarcoidosis


  • Human African trypanosomiasis[citation needed]


  • Drug abuse[citation needed]


  • Obesity[citation needed]




Rare disorders



  • Lipoproteinlipase deficiency

  • Multiple sulfatase deficiency

  • Osteopetrosis

  • Adult-onset Still's disease (AOSD)



References





  1. ^ abcdefghij medcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009


  2. ^ abcdefghijklm GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009


  3. ^ Xavier, Mariana (2010). "Pathogenesis of Brucella spp". The Open Veterinary Science Journal. 4: 109–118..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{quotes:"""""""'""'"}.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  4. ^ "Typhoid & Paratyphoid Fever - Chapter 3 - 2016 Yellow Book - Travelers' Health - CDC".




External links











Classification
D



  • ICD-10: R16.2


  • ICD-9-CM: 571.8
External resources

  • MedlinePlus: 003275


  • National Niemann Pick Disease Foundation

  • Hide and Seek Foundation For Lysosomal Disease Research














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