HTN3
| Histatin 3 组氨素3 | |||||||||||||
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| 标识 | |||||||||||||
| 代号 | HTN3; HIS2; HTN2; HTN5 | ||||||||||||
| 扩展标识 | 遗传学：142702 同源基因：133553 GeneCards: HTN3 Gene | ||||||||||||
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| RNA表达模式 | |||||||||||||
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更多表达数据 | |||||||||||||
| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 3347 | n/a | |||||||||||
| Ensembl | ENSG00000205649 | n/a | |||||||||||
| UniProt | P15516 | n/a | |||||||||||
| mRNA序列 | NM_000200 | n/a | |||||||||||
| 蛋白序列 | NP_000191 | n/a | |||||||||||
| 基因位置 | Chr 4: 70.89 – 70.9 Mb | n/a | |||||||||||
PubMed查询 | [1] | n/a | |||||||||||
HTN3，是一能夠指導組氨素3合成的基因片段[1][2]。
功能
HTN3基因表達的初級產物爲組氨素3。組氨素是一類存在於唾液中的富含組氨酸的蛋白質，控制其合成的基因位點除了HTN3之外，還有H1N1。組氨素3在合成完畢後，還可以通過蛋白水解轉化成其它的組氨素（比如組氨素4-6）。能控制組氨素3合成的等位基因爲HIS2[3]。
| 等位基因 | 基因 | 蛋白質 |
|---|---|---|
| HIS1 | HTN1 | 組氨素 1 |
| HIS2 | HTN3 | 組氨素 3 → 組氨素 4-6 |
參考
^ Entrez Gene: HTN3 histatin 3.
^ Sabatini LM, Azen EA. Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2). Biochem. Biophys. Res. Commun. April 1989, 160 (2): 495–502. PMID 2719677. doi:10.1016/0006-291X(89)92460-1.
^ Oudhoff MJ, Bolscher JG, Nazmi K, Kalay H, van 't Hof W, Amerongen AV, Veerman EC. Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay. FASEB J. November 2008, 22 (11): 3805–12. PMID 18650243. doi:10.1096/fj.08-112003.
拓展閱讀
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