Hepatosplenomegaly
















Hepatosplenomegaly
Specialty
Gastroenterology Edit this on Wikidata

Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly). Hepatosplenomegaly can occur as the result of acute viral hepatitis, infectious mononucleosis, and histoplasmosis or it can be the sign of a serious and life-threatening lysosomal storage disease. Systemic venous hypertension can also increase the risk for developing hepatosplenomegaly, which may be seen in those patients with right-sided heart failure.




Contents






  • 1 Common causes


  • 2 Rare disorders


  • 3 References


  • 4 External links





Common causes





  • Infection:

    • Acute viral hepatitis[1][2]


    • Infectious mononucleosis[1][2]


    • Cytomegalovirus[1][2]


    • Rubella[1]


    • Brucella infection[3]


    • Hyper active malaria syndrome[1]


    • Leishmaniasis[1]

    • Fasciolosis


    • Typhoid fever[4]


    • Schistosomiasis or filariasis importants

    • Septicemic plague

    • Histoplasmosis




  • Hematologic diseases:


    • Myeloproliferative disease[1][2]


    • Leukaemia[1][2]


    • Lymphoma[1][2]


    • Pernicious anaemia[2]


    • Sickle cell anaemia[2]


    • Thalassaemia[2]


    • Myelofibrosis[1]




  • Metabolic disease:


    • Niemann-Pick disease[citation needed]


    • Gaucher's disease[citation needed]


    • Hurler's syndrome[citation needed]




  • Chronic liver disease and portal hypertension:

    • Chronic active hepatitis[2]



  • Amyloidosis[2]


  • Acromegaly[2]


  • Systemic lupus erythematosus[2]

  • Sarcoidosis


  • Human African trypanosomiasis[citation needed]


  • Drug abuse[citation needed]


  • Obesity[citation needed]




Rare disorders



  • Lipoproteinlipase deficiency

  • Multiple sulfatase deficiency

  • Osteopetrosis

  • Adult-onset Still's disease (AOSD)



References





  1. ^ abcdefghij medcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009


  2. ^ abcdefghijklm GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009


  3. ^ Xavier, Mariana (2010). "Pathogenesis of Brucella spp". The Open Veterinary Science Journal. 4: 109–118..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{quotes:"""""""'""'"}.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  4. ^ "Typhoid & Paratyphoid Fever - Chapter 3 - 2016 Yellow Book - Travelers' Health - CDC".




External links











Classification
D



  • ICD-10: R16.2


  • ICD-9-CM: 571.8
External resources

  • MedlinePlus: 003275


  • National Niemann Pick Disease Foundation

  • Hide and Seek Foundation For Lysosomal Disease Research














-

Popular posts from this blog

Lambaréné

Image
Place in Moyen-Ogooué, Gabon Lambaréné Street in Lambaréné Lambaréné Location in Gabon Coordinates: 0°41′18″S 10°13′55″E  /  0.68833°S 10.23194°E  / -0.68833; 10.23194 Coordinates: 0°41′18″S 10°13′55″E  /  0.68833°S 10.23194°E  / -0.68833; 10.23194 Country   Gabon Province Moyen-Ogooué Population (2013 census)  • Total 38,775 Lambaréné is a town and the capital of Moyen-Ogooué in Gabon. With a population of 38,775 as of 2013, it is located 75 kilometres south of the equator. Lambaréné is based in the Central African Rainforest at the river Ogooué. This river divides the city into 3 districts: Rive Gauche, Ile Lambaréné and Rive Droite. The Albert Schweitzer Hospital and the districts Adouma and Abongo are located on Rive Droite. The districts Atongowanga, Sahoty, Dakar, Grand Village, Château, Lalala and Bordamur build the Ile Lambaréné. The majority of the people in Lambaréné live in the district Isaac located on Rive Gauche. This distr
Read more

Chris Pine

Image
Not to be confused with Christopher Pyne or Chris Pyne. Chris Pine Pine in 2018 Born Christopher Whitelaw Pine ( 1980-08-26 ) August 26, 1980 (age 38) Los Angeles, California, U.S. Alma mater UC Berkeley Occupation Actor Years active 2003–present Parent(s) Robert Pine Gwynne Gilford Relatives Anne Gwynne (grandmother) Christopher Whitelaw Pine (born August 26, 1980) [1] [2] is an American actor. Pine made his feature debut as Lord Devereaux in The Princess Diaries 2: Royal Engagement (2004). He is known for playing James T. Kirk in the Star Trek reboot film series (2009–2016), Will in Unstoppable (2010), Cinderella's Prince in Into the Woods (2014), Jack Ryan in Jack Ryan: Shadow Recruit (2014), Toby Howard in Hell or High Water (2016), Bernie Webber in The Finest Hours (2016), Steve Trevor in Wonder Woman (2017), and Dr. Alexander Murry in A Wrinkle in Time (2018). Contents 1 Early life 2 Career 2.1 2003–200
Read more

Kashihara Line

Image
Kashihara Line   B   A Kashihara Line train passing Yakushi-ji temple Overview Native name 橿原線 Type Commuter rail System Kintetsu Railway Locale Nara, Nara, Japan Yamtokoriyama, Nara, Japan Tenri, Nara, Japan Kawanishi, Nara, Japan Miyake, Nara, Japan Tawaramoto, Nara, Japan Kashihara , Nara, Japan Termini Yamato-Saidaiji Kashiharajingu-mae Stations 17 Operation Opened April 1, 1921 ; 98 years ago  ( 1921-04-01 ) Owner Kintetsu Railway Character Commuter rail Technical Line length 23.8 km (14.8 mi) Track gauge 1,435 mm ( 4 ft  8   1 ⁄ 2  in ) Minimum radius 240 m Electrification 1,500 V DC Overhead lines Operating speed 100 km/h (60 mph) [1] The Kashihara Line ( 橿原線 , Kashihara-sen ) is a 23.8 km (14.8 mi) north-south bound railway line in Nara Prefecture, Japan, owned and operated by the Kintetsu Railway, a private railway operator. It connects Yamato-Saidaiji Station and Kashiharajingu
Read more