金刚乙胺
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醫學聲明。如需专业意见请咨询专业人士。
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金刚乙胺
|
| 系统（IUPAC）命名名称 |
|---|
(RS)-1-(1-adamantyl)ethanamine
|
| 临床数据 |
|---|
| 妊娠分级 |
|
| 给药途径 |
口 |
| 合法狀態 |
|---|
| 合法状态 |
US: 处方药（℞-only）
CN: 处方药 
|
药代动力学数据
|
|---|
| 生物利用度 |
容易吸收 |
| 蛋白结合度 |
40% |
| 代谢 |
在肝脏中被羟基化并与葡糖醛酸结合
|
| 生物半衰期 |
25.4 ± 6.3 小時 |
| 排泄 |
肾脏
|
| 识别信息 |
|---|
| CAS注册号 |
13392-28-4 |
| ATC代码 |
J05AC02 |
| PubChem |
CID 5071
|
| DrugBank |
APRD01219
|
化学信息
|
|---|
| 化学式 |
C12H21N
|
| 摩尔质量 |
179.302 g/mol
|
SMILES
CC(N)C12CC3CC(C1)CC(C2)C3
|
金刚乙胺（Rimantadine）是一种抗病毒药，属于三环胺类，对A型流感病毒有预防和治疗作用，且作用强于金刚烷胺。金刚乙胺的中枢神经副作小于金刚烷胺。金刚乙胺通过抑制特异蛋白的释放，而干扰病毒脱壳，它能抑制逆转录酶而发挥抗病毒活性或抑制病毒特异性RNA的合成，但却不影响病毒的吸附和穿入。金刚乙胺在肾排泄前被代谢。
相关药物
外部連結
- U.S. FDA press release announcing rimantadine's approval
- U.S. Center for Drug Evaluation and Research rimantadine description
- U.S. NIH rimantadine description
- U.S. CDC flu anti-viral treatment information
抗病毒药物
|
|---|
|
| 疱疹病毒 （DNA） |
嘌呤类似物（阿昔洛韦、泛昔洛韦、更昔洛韦、喷昔洛韦、万乃洛韦、缬更昔洛韦） · 阿糖腺苷
嘧啶类似物（碘苷、三氟胸苷） · 溴夫定 · 西多福韦
二十二烷醇 · 福米韦生 · 膦甲酸 · 曲金刚胺
|
|
| 人乳头状瘤病毒 （DNA） |
咪喹莫特 · 鬼臼毒素
|
|
乙肝病毒 （DNA） |
阿德福韦 · Clevudine · INF alfa-2b · PEG- INF alfa-2b · 恩替卡韦 · 拉米夫定 · 替比夫定 · 泰诺福韦
|
|
丙肝 （RNA） |
PEG- INF alfa-2b · 利巴韦林 · Taribavirin† · Boceprevir† · Telaprevir†
|
|
小核糖核酸病毒 （RNA） |
普利康那利 (Pleconaril)†
|
|
| 流感病毒 (RNA, V) |
阿比朵尔
金刚烷／M2离子通道蛋白抑制剂（金刚烷胺、金刚乙胺）
神经胺酶抑制剂（奥司他韦、扎那米韦、帕拉米韦 †） |
|
| HIV（逆转录病毒） |
参见抗HIV药物
|
|
| 其他 |
肌苷、干扰素
|
|
†临床研究中，FDA未批准。
|
|
抗帕金森病药物（N04）
|
|---|
|
| 多巴胺能 |
多巴胺前驅物/前体药物
|
|
|
多巴胺受體激動劑
|
- 阿朴吗啡
- 溴隱亭
- 卡麦角林
- Dihydroergocryptine
- Lisuride
- 培高利特
- 吡贝地尔
- 普拉克索
- 罗匹尼罗
- 罗替戈汀
|
|
MAO-B抑制劑
|
|
|
COMT抑制劑
|
|
|
AAAD抑制劑
|
|
|
|
| 抗膽鹼劑 |
- 苯扎托品
百比停#
- 波那普令
- 氯苯沙明
- Cycrimine
- 茶苯海明
- 苯海拉明
- 乙苯海拉明
- 乙苯托品
- 马扎替可
- 美噻吨
- 盐酸奥芬那君
- 芬格鲁胺
- 吡咯庚汀
- 丙环定
- 普罗吩胺
- 苯海索
- 曲帕替平
|
|
| 其他 |
- 金刚烷胺
- Budipine
黄嘌呤（如咖啡因）
- 金刚乙胺
|
|
#世卫基本药物（WHO-EM）
‡从市场撤回
臨床試驗：
|
|
致幻剂
|
|---|
|
迷幻药物
5-HT2AR 激動劑
|
Lysergamides |
- AL-LAD
- ALD-52
- BU-LAD
- CYP-LAD
- IP-LAD
- Diallyllysergamide
- Dimethyllysergamide
- 麦角新碱
- ETH-LAD
- LAE-32
- LPD-824
- LSA
- LSD
- LSD-Pip
- LSH
- LSM-775
- Lysergic acid 2-butyl amide
- LSZ
- Lysergic acid 3-pentyl amide
- Methylergometrine
- Methylisopropyllysergamide
- Methysergide
- N1-Methyl-lysergic acid diethylamide
- PARGY-LAD
- PRO-LAD
|
|
取代苯乙胺 |
|
|
哌嗪 |
- para-Fluorophenylpiperazine
- Trifluoromethylphenylpiperazine
- meta-Chlorophenylpiperazine
|
|
色胺 |
- 1-Methyl-5-methoxy-diisopropyltryptamine
- 2,N,N-TMT
- 4,5-DHP-AMT
- 4,5-DHP-DMT
- 4-Acetoxy-DALT
- 4-Acetoxy-DET
- 4-Acetoxy-DiPT
- 4-Acetoxy-DMT
- 4-Acetoxy-DPT
- 4-AcO-MiPT
- 4-HO-5-MeO-DMT
- 4-HO-DBT
- 4-HO-DPT
- 4-HO-MET
- 4-HO-MPMI
- 4-HO-MPT
- 4,N,N-TMT
- 4-Propionyloxy-DMT
- 5,6-diBr-DMT
- 5-AcO-DMT
- 5-Bromo-DMT
- 5-Me-MIPT
- 5-MeO-2,N,N-TMT
- 5-MeO-4,N,N-TMT
- 5-MeO-α,N,N-TMT
- 5-MeO-α-ET
- 5-MeO-α-MT
- 5-MeO-DALT
- 5-MeO-DET
- 5-Methoxy-diisopropyltryptamine
- 5-甲氧基二甲基色胺
- 5-MeO-DPT
- 5-MeO-EiPT
- 5-MeO-MET
- 5-MeO-MiPT
- 5-MeO-MPMI
- 5,N,N-TMT
- 7,N,N-TMT
- α-ET
- α-MT
- α,N,N-TMT
- Aeruginascin
- Baeocystin
- 蟾毒色胺
- DALT
- DBT
- DCPT
- DET
- DIPT
- DMT
- DPT
- EiPT
- 4-羟二乙基色胺
- 4-磷酸二乙基色胺
- 4-羟二异丙基色胺
- MET
- Miprocin
- MiPT
- Norbaeocystin
- PiPT
- 脱磷酸裸盖菇素
- 裸盖菇素
|
|
其它藥物 |
- AL-38022A
- Elemicin
- Ibogaine
- Myristicin
- Noribogaine
- Voacangine
|
|
|
游離藥物
NMDAR拮抗劑
|
金刚烷 |
|
|
Arylcyclohexylamines
|
- 3-MeO-PCP
- 4-MeO-PCP
- Dieticyclidine
- Diphenidine
- Esketamine
- Ethketamine
- Eticyclidine
- Gacyclidine
- 氯胺酮
- Methoxetamine
- Methoxyketamine
- Neramexane
- PCPr
- Phencyclidine
- Rolicyclidine
- Tenocyclidine
- Tiletamine
|
|
Morphinans
|
- Dextrallorphan
- 右美沙芬
- Dextrorphan
- Racemethorphan
- Racemorphan
|
|
其它藥物 |
- 2-MDP
- 8A-PDHQ
- Aptiganel
- Dexoxadrol
- Dizocilpine
- Etoxadrol
- Ibogaine
- Midafotel
- NEFA
- 一氧化二氮
- Noribogaine
- Perzinfotel
- Remacemide
- Selfotel
- 氙
|
|
|
致谵妄药
mAChR拮抗劑
|
- 二苯乙醇酸-3-喹咛环酯
- 阿托品
- Benactyzine
- Benzatropine
- Benzydamine
- 百比停
- BRN-1484501
- 溴苯那敏
- CAR-226,086
- CAR-301,060
- CAR-302,196
- CAR-302,282
- CAR-302,368
- CAR-302,537
- CAR-302,668
- Chloropyramine
- 氯苯那敏
- Clemastine
- CS-27349
- Cyclizine
- Cyproheptadine
- Dicycloverine
- Dimenhydrinate
- 苯海拉明
- Ditran
- Doxylamine
- EA-3167
- EA-3443
- EA-3580
- EA-3834
- Flavoxate
- 天仙子胺
- Meclozine
- Mepyramine
- N-Ethyl-3-piperidyl benzilate
- N-Methyl-3-piperidyl benzilate
- Orphenadrine
- Oxybutynin
- 非尼拉敏
- Phenyltoloxamine
- Procyclidine
- 鹽酸異丙嗪
- 東莨菪鹼
- Tolterodine
- 苯海索
- Tripelennamine
- Triprolidine
- WIN-2299
|
|
| 其它相關藥物 |
大麻素
CB1R激动剂
|
大麻生物鹼 |
- Cannabinol
- 四氢大麻酚
- THCV
- (Cannabidiol有不同的作用機制)
|
|
大麻素綜合劑 |
- CP 47,497
- CP 55,244
- CP 55,940
- DMHP
- HU-210
- JWH-018
- JWH-030
- JWH-073
- JWH-081
- JWH-200
- JWH-250
- Levonantradol
- Nabilone
- Nabitan
- Parahexyl
- WIN 55,212-2
|
|
|
D2R 激動劑
|
- Aporphine
- 溴隱亭
- Cabergoline
- Lisuride
- Memantine
- Nuciferine
- Pergolide
- Piribedil
- Pramipexole
- Ropinirole
Rotigotine
同樣間接D2激動劑，比如dopamine reuptake inhibitor(可卡因、哌甲酯)，releasing agent(苯丙胺、甲基苯丙胺)及前体 (L-多巴).
|
|
GABAAR激动剂
|
- 右佐匹克隆
- Gaboxadol
- 鹅膏蕈氨酸
- 蠅蕈素
- 扎來普隆
- 唑吡坦
- 佐匹克隆
|
|
Inhalants
混合MOA
|
|
|
κOR激動劑
|
- 2-EMSB
- 2-MMSB
- Alazocine
- Bremazocine
- Butorphanol
- Cyclazocine
- Cyprenorphine
- Dextrallorphan
- 地佐辛
- Enadoline
- Herkinorin
- HZ-2
- Ibogaine
- Ketazocine
- LPK-26
- Metazocine
- 纳布啡
- Nalorphine
- Noribogaine
- 喷他佐辛
- Phenazocine
- Salvinorin A
- Spiradoline
- Tifluadom
- U-50488
- U-69,593
|
|
MAO抑製劑 |
- Harmaline
- Harmine
- Tetrahydroharmine
- 育亨宾
|
|
σR激动剂
|
- DMT
- Dextrallorphan
- 右美沙芬
- 右啡烷
- 那可丁
|
|
其它藥物 |
|
|
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维基百科中的醫療相关内容仅供参考，詳見醫學聲明。如需专业意见请咨询专业人士。
